Amino Acid Conservation Scores =============================== - POS: The position of the Amino Acid in the SEQRES derived sequence. - SEQ: The SEQRES derived sequence in one letter code. - SCORE: The normalized conservation scores. - COLOR: The color scale representing the conservation scores (9 - conserved, 1 - variable). - CONFIDENCE INTERVAL: When using the bayesian method for calculating rates, a confidence interval is assigned to each of the inferred evolutionary conservation scores. - CONFIDENCE INTERVAL COLORS: When using the bayesian method for calculating rates. The color scale representing the lower and upper bounds of the confidence interval. - B/E: Burried (b) or Exposed (e) residue. - FUNCTION: functional (f) or structural (s) residue (f - highly conserved and exposed, s - highly conserved and burried). - MSA DATA: The number of aligned sequences having an amino acid (non-gapped) from the overall number of sequences at each position. - RESIDUE VARIETY: The residues variety at each position of the multiple sequence alignment. POS SEQ SCORE COLOR CONFIDENCE INTERVAL CONFIDENCE INTERVAL COLORS B/E FUNCTION MSA DATA RESIDUE VARIETY (normalized) 1 A -0.752 7 -1.350, -0.399 9,6 e 3/37 A 2 S -1.231 9 -1.599, -1.094 9,8 e f 21/37 S 3 K 0.630 4 -0.127, 1.156 5,3 e 27/37 A, E, K, R, S, Y 4 G -1.118 8 -1.498, -0.903 9,8 e f 32/37 G 5 E -0.612 7 -1.031, -0.314 8,6 e 33/37 A, E, G 6 E 0.538 4 -0.127, 0.895 5,4 e 35/37 E, K, L, M, Q, R 7 L -0.432 6 -0.903, -0.127 8,5 b 35/37 I, L, T, Y 8 F -1.045 8 -1.420, -0.838 9,8 b 35/37 F, L 9 T 1.661 3 0.684, 2.026 4,2 e 35/37 E, H, K, N, Q, R, T 10 G 0.356 4 -0.223, 0.684 6,4 e 36/37 E, G, K, N, Q, S 11 V 0.226 5 -0.314, 0.684 6,4 e 36/37 E, I, K, P, V 12 V -0.322 6 -0.771, -0.022 7,5 b 36/37 I, L, M, V 13 P -0.725 7 -1.156, -0.481 9,6 e 36/37 K, P, T 14 I 0.330 5 -0.223, 0.684 6,4 b 36/37 F, I, L, V, Y 15 L 0.498 4 -0.127, 0.895 5,4 b 36/37 I, K, L, Q, V 16 V 0.301 5 -0.314, 0.684 6,4 b 36/37 A, C, I, L, M, T, V 17 E -1.257 9 -1.498, -1.094 9,8 e f 36/37 E, R 18 L 0.069 5 -0.481, 0.504 6,4 b 36/37 F, L, M, V 19 D 0.131 5 -0.399, 0.504 6,4 e 36/37 D, E, K, N 20 G -0.334 6 -0.838, -0.022 8,5 e 36/37 A, C, G 21 D -0.290 6 -0.771, -0.022 7,5 e 36/37 D, E, I, N, Q 22 V -1.096 8 -1.420, -0.903 9,8 b 36/37 I, V 23 N -0.557 7 -0.903, -0.314 8,6 e 36/37 D, E, H, N 24 G -0.621 7 -1.094, -0.314 8,6 e 36/37 D, E, G 25 H -0.134 5 -0.557, 0.213 7,5 e 36/37 E, H, I, M, Q, R 26 K -0.196 6 -0.631, 0.090 7,5 e 36/37 I, K, R, T, V 27 F -1.321 9 -1.599, -1.219 9,9 b s 36/37 F 28 S -0.274 6 -0.703, -0.022 7,5 e 36/37 A, I, K, M, S, T 29 V -0.588 7 -0.968, -0.314 8,6 b 36/37 I, V 30 S 0.253 5 -0.314, 0.684 6,4 e 36/37 H, I, K, R, S, T 31 G -1.215 9 -1.599, -1.031 9,8 e f 36/37 G 32 E -0.420 6 -0.838, -0.127 8,5 e 36/37 E, K, N, V 33 G -1.215 9 -1.599, -1.031 9,8 e f 36/37 G 34 E 1.032 4 0.351, 1.502 4,3 e 36/37 E, F, H, I, K, Q, T, V, W, Y 35 G -1.215 9 -1.599, -1.031 9,8 e f 36/37 G 36 D -0.631 7 -1.031, -0.399 8,6 e 36/37 D, E, K, N 37 A -0.692 7 -1.094, -0.481 8,6 e 36/37 A, G, P, S 38 T 0.871 4 0.213, 1.156 5,3 e 36/37 A, D, E, F, G, N, S, T 39 Y 1.574 3 0.684, 2.026 4,2 e 36/37 E, H, I, K, M, N, Q, S, T, V, Y 40 G -1.215 9 -1.599, -1.031 9,8 b s 36/37 G 41 K 1.202 3 0.504, 1.502 4,3 e 36/37 I, K, L, M, N, R, T, V 42 L 0.808 4 0.090, 1.156 5,3 b 36/37 H, I, L, M, T, V 43 T 0.631 4 -0.022, 1.156 5,3 e 36/37 D, E, H, K, T, V 44 L 1.005 4 0.213, 1.502 5,3 b 36/37 A, G, I, L, M, S, T 45 K -0.037 5 -0.557, 0.351 7,4 e 36/37 I, K, L, Q, R, S 46 F 0.177 5 -0.399, 0.504 6,4 b 36/37 F, H, L, Y 47 I -0.608 7 -1.031, -0.314 8,6 b 36/37 I, V 48 C -0.458 6 -0.968, -0.127 8,5 b 36/37 C, K, V 49 T -1.095 8 -1.420, -0.903 9,8 e f 36/37 E, S, T 50 T 0.065 5 -0.399, 0.351 6,4 e 37/37 E, G, K, S, T 51 G -1.216 9 -1.599, -1.031 9,8 e f 37/37 G 52 K -0.414 6 -0.838, -0.127 8,5 e 37/37 D, E, K, P, R, T 53 L 0.040 5 -0.481, 0.351 6,4 e 37/37 I, L, M, V 54 P -1.278 9 -1.599, -1.156 9,9 e f 37/37 P 55 V -0.634 7 -1.031, -0.399 8,6 b 37/37 C, F, I, L, V 56 P -0.759 7 -1.156, -0.481 9,6 e 37/37 A, P, S 57 W -0.909 8 -1.350, -0.631 9,7 b 37/37 W, Y 58 P -0.009 5 -0.557, 0.351 7,4 e 37/37 A, D, E, P, S, T, V 59 T -0.442 6 -0.838, -0.127 8,5 b 37/37 A, I, S, T 60 L -0.642 7 -1.094, -0.399 8,6 b 37/37 I, L 61 V 0.551 4 -0.022, 0.895 5,4 b 37/37 I, L, S, T, V 62 T -0.659 7 -1.031, -0.399 8,6 b 37/37 C, H, S, T 63 T -0.339 6 -0.771, -0.022 7,5 b 37/37 A, N, S, T 64 F 0.546 4 -0.127, 0.895 5,4 b 37/37 F, L, M, V 65 S 0.319 5 -0.223, 0.684 6,4 e 37/37 A, C, G, Q, S, T 66 Y -0.887 8 -1.283, -0.631 9,7 e f 37/37 W, Y 67 G -1.216 9 -1.599, -1.031 9,8 b s 37/37 G 68 V 1.019 4 0.351, 1.502 4,3 b 37/37 A, F, G, I, L, N, Q, V 69 Q 1.279 3 0.504, 2.026 4,2 e 37/37 F, K, L, M, Q, R, V 70 C -0.692 7 -1.156, -0.399 9,6 b 37/37 C, V 71 F -1.322 9 -1.599, -1.219 9,9 b s 37/37 F 72 S 1.652 3 0.684, 2.026 4,2 b 37/37 A, C, S, T, V 73 R -0.878 8 -1.219, -0.631 9,7 e f 37/37 K, Q, R 74 Y -1.326 9 -1.599, -1.219 9,9 b s 37/37 Y 75 P -1.008 8 -1.350, -0.771 9,7 e f 37/37 G, P 76 D 1.402 3 0.504, 2.026 4,2 e 37/37 D, E, H, K, N, P, R, S, V 77 H 0.349 5 -0.223, 0.684 6,4 e 37/37 D, E, G, H, N, S, V 78 M -1.004 8 -1.283, -0.838 9,8 b 37/37 I, L, M, V 79 K 0.443 4 -0.127, 0.895 5,4 e 37/37 A, K, N, P, R 80 R 0.842 4 -0.022, 1.502 5,3 e 19/37 M, Q, R 81 H -0.431 6 -1.031, -0.022 8,5 e 19/37 H, N 82 D -1.400 9 -1.691, -1.283 9,9 e f 37/37 D 83 F -0.426 6 -0.903, -0.127 8,5 b 37/37 F, H, Y 84 F -0.172 6 -0.703, 0.213 7,5 b 37/37 F, I, P, V, Y 85 K -1.429 9 -1.691, -1.350 9,9 e f 37/37 K 86 S -1.329 9 -1.599, -1.219 9,9 e f 37/37 Q, S 87 A 0.078 5 -0.399, 0.504 6,4 e 37/37 A, C, L, S, T 88 M -0.919 8 -1.219, -0.703 9,7 e f 37/37 F, L, M, Q 89 P -1.278 9 -1.599, -1.156 9,9 e f 37/37 P 90 E -0.148 5 -0.631, 0.213 7,5 e 37/37 D, E, K, R, S, T 91 G -1.216 9 -1.599, -1.031 9,8 e f 37/37 G 92 Y -1.326 9 -1.599, -1.219 9,9 e f 37/37 Y 93 V 1.077 3 0.351, 1.502 4,3 b 37/37 H, I, S, T, V 94 Q -1.149 9 -1.420, -0.968 9,8 e f 37/37 K, Q, W 95 E -0.960 8 -1.283, -0.771 9,7 e f 36/37 D, E, K, T, X 96 R -1.399 9 -1.691, -1.283 9,9 e f 37/37 R 97 T -0.372 6 -0.771, -0.127 7,5 e 37/37 H, I, K, M, S, T 98 I -0.955 8 -1.283, -0.771 9,7 b 37/37 I, M, S, V 99 F 0.927 4 0.213, 1.502 5,3 e 37/37 F, H, K, N, S, T, Y 100 F -0.644 7 -1.094, -0.399 8,6 b 37/37 F, Y 101 K -0.053 5 -0.557, 0.213 7,5 e 37/37 D, E, K, Q, R, V 102 D 0.307 5 -0.223, 0.684 6,4 e 37/37 D, G, K, N 103 D -1.174 9 -1.498, -1.031 9,8 e f 37/37 D, Q 104 G -1.216 9 -1.599, -1.031 9,8 e f 37/37 G 105 N 3.147 1 2.026, 3.368 2,1 e 37/37 A, E, H, K, N, Q, S, T, V, Y 106 Y -0.047 5 -0.557, 0.351 7,4 e 37/37 C, F, L, W, Y 107 K -0.189 6 -0.631, 0.090 7,5 e 37/37 D, E, K, R, T 108 T -0.538 7 -0.903, -0.314 8,6 b 37/37 S, T, V 109 R -0.291 6 -0.771, -0.022 7,5 e 37/37 A, H, K, R, T, V 110 A -0.489 7 -0.903, -0.223 8,6 b 37/37 A, G, H, Q, S 111 E 0.507 4 -0.127, 0.895 5,4 e 37/37 D, E, K, M, T, V 112 V -0.419 6 -0.838, -0.127 8,5 b 37/37 I, L, V 113 K -0.937 8 -1.283, -0.771 9,7 e f 37/37 K, R, T 114 F 0.230 5 -0.314, 0.684 6,4 e 37/37 F, L, M, Y 115 E -1.447 9 -1.691, -1.350 9,9 e f 37/37 E 116 G 0.135 5 -0.399, 0.504 6,4 e 37/37 D, E, G, H, K, N, R, S 117 D -0.127 5 -0.703, 0.213 7,5 e 37/37 D, G, N, R 118 T -0.320 6 -0.771, -0.022 7,5 e 37/37 A, C, S, T, V 119 L -0.376 6 -0.838, -0.022 8,5 b 37/37 F, I, L, V 120 V -0.480 6 -0.903, -0.223 8,6 b 37/37 F, V, Y 121 N -1.195 9 -1.498, -1.031 9,8 b s 37/37 E, N, Y 122 R -1.169 9 -1.498, -1.031 9,8 e f 37/37 E, R 123 I -1.084 8 -1.420, -0.903 9,8 b 37/37 I, V 124 E 0.636 4 -0.022, 1.156 5,3 e 37/37 E, K, N, R, S, T, V 125 L -0.074 5 -0.631, 0.351 7,4 b 37/37 F, I, L, V 126 K 0.304 5 -0.223, 0.684 6,4 e 37/37 D, K, N, R, T, Y 127 G -1.216 9 -1.599, -1.031 9,8 e f 37/37 G 128 I 2.985 1 2.026, 3.368 2,1 e 37/37 A, E, G, I, M, Q, R, S, T, V 129 D 0.049 5 -0.557, 0.504 7,4 e 37/37 D, G, N 130 F -1.104 8 -1.420, -0.903 9,8 b 37/37 F, L 131 K -0.026 5 -0.557, 0.351 7,4 e 37/37 D, K, N, P, R, S 132 E 0.003 5 -0.481, 0.351 6,4 e 37/37 D, E, K, P, R, S 133 D -0.605 7 -1.031, -0.314 8,6 e 37/37 D, G, K, N, S 134 G -1.216 9 -1.599, -1.031 9,8 b s 37/37 G 135 N -0.466 6 -0.838, -0.223 8,6 e 37/37 H, L, N, P 136 I -0.942 8 -1.283, -0.771 9,7 b 37/37 I, V 137 L -0.618 7 -1.031, -0.314 8,6 b 37/37 C, F, L, M 138 G 0.359 4 -0.314, 0.895 6,4 e 37/37 G, K, Q, R 139 H -0.751 7 -1.094, -0.557 8,7 e 37/37 H, K, M, N 140 K 0.334 5 -0.223, 0.684 6,4 e 37/37 K, N, Q, R 141 L 0.181 5 -0.399, 0.504 6,4 b 37/37 I, L, M, V, Y 142 E 0.769 4 0.090, 1.156 5,3 e 37/37 A, D, E, H, K, L, R, V 143 Y 1.309 3 0.504, 2.026 4,2 e 35/37 A, D, E, F, I, L, W, Y 144 N 0.454 4 -0.127, 0.895 5,4 e 37/37 C, D, E, H, N, Q, S, T, V, Y 145 Y 3.052 1 2.026, 3.368 2,1 e 36/37 A, C, E, F, G, M, P, S, T, Y 146 N 0.809 4 0.090, 1.156 5,3 e 34/37 I, K, L, N, P, S, T 147 S 0.470 4 -0.127, 0.895 5,4 e 34/37 A, D, G, N, P, S, T, V 148 H 1.276 3 0.504, 2.026 4,2 e 34/37 D, E, G, H, I, N, Q, S, T, V 149 N 2.557 1 1.502, 3.368 3,1 e 34/37 A, C, F, I, K, M, N, P, S, T, V 150 V 0.391 4 -0.223, 0.895 6,4 b 35/37 A, I, L, M, S, T, V 151 Y -0.338 6 -0.838, -0.022 8,5 b 35/37 M, S, T, V, Y 152 I -0.052 5 -0.557, 0.351 7,4 b 35/37 I, L, V, Y 153 M 0.648 4 -0.022, 1.156 5,3 b 34/37 F, L, M, T, V, W 154 A 1.066 3 0.351, 1.502 4,3 e 34/37 A, G, P, S, T 155 D -0.221 6 -0.703, 0.090 7,5 e 34/37 D, E, G, N, T, Y 156 K 0.919 4 0.213, 1.502 5,3 e 30/37 D, K, Q, R, S, T, V 157 Q 1.637 3 0.684, 2.026 4,2 e 30/37 A, E, G, K, L, Q, R, V 158 K -0.153 5 -0.631, 0.213 7,5 e 34/37 G, K, N, R, T 159 N -0.020 5 -0.481, 0.351 6,4 e 34/37 A, D, E, G, H, K, N, T 160 G -0.557 7 -1.031, -0.223 8,6 e 34/37 A, E, G 161 I 0.690 4 -0.022, 1.156 5,3 b 34/37 A, I, L, M, Q, Y 162 K 0.529 4 -0.022, 0.895 5,4 e 34/37 K, N, R, V 163 V 2.174 2 1.156, 3.368 3,1 b 34/37 A, C, G, I, L, P, S, V 164 N 1.888 2 0.895, 3.368 4,1 e 34/37 A, C, E, I, K, L, M, N, V, Y 165 F 1.281 3 0.351, 2.026 4,2 b 34/37 C, F, I, Y 166 K 0.296 5 -0.223, 0.684 6,4 e 34/37 C, E, I, K, N, R, S, T 167 I 0.422 4 -0.127, 0.895 5,4 e 33/37 I, K, N, Q, T, V 168 R 0.461 4 -0.127, 0.895 5,4 e 32/37 A, I, L, M, R, T, V 169 H 0.672 4 -0.022, 1.156 5,3 b 32/37 F, H, I, S, T, Y 170 N 0.134 5 -0.399, 0.504 6,4 e 32/37 D, E, K, N, P 171 I 0.551 4 -0.022, 0.895 5,4 b 32/37 I, L, T, V 172 E 1.309 3 0.504, 2.026 4,2 e 32/37 E, I, K, M, T, V 173 D -0.506 7 -0.968, -0.223 8,6 e 32/37 D, G 174 G -0.147 5 -0.771, 0.213 7,5 e 31/37 E, G, S, V 175 S 1.315 3 0.504, 2.026 4,2 e 31/37 D, G, H, K, N, S, T 176 V 0.793 4 0.090, 1.156 5,3 e 31/37 E, H, I, Q, R, V, Y 177 Q -0.283 6 -0.703, -0.022 7,5 e 31/37 D, H, I, K, L, Q, V 178 L 1.160 3 0.351, 1.502 4,3 b 31/37 A, C, I, L, M, S, V 179 A -0.496 7 -0.903, -0.223 8,6 b 31/37 A, C, I, T, V 180 D 1.773 2 0.684, 2.026 4,2 e 31/37 A, D, I, K, M, N, R, S, T 181 H -0.411 6 -0.838, -0.127 8,5 e 31/37 H, I, K, L, T 182 Y 2.023 2 0.895, 3.368 4,1 e 31/37 A, D, E, Q, R, S, T, V, Y 183 Q -1.437 9 -1.691, -1.350 9,9 e f 31/37 Q 184 Q 0.969 4 0.213, 1.502 5,3 e 31/37 A, F, K, L, M, Q, R, T, V 185 N -0.974 8 -1.283, -0.771 9,7 e f 31/37 H, I, N, Q 186 T 0.496 4 -0.127, 0.895 5,4 e 31/37 I, K, R, T, V, Y 187 P -1.227 9 -1.599, -1.031 9,8 e f 31/37 P 188 I -0.304 6 -0.771, -0.022 7,5 e 31/37 I, L 189 G -0.710 7 -1.156, -0.399 9,6 e 31/37 A, G, S 190 D 1.770 2 0.684, 2.026 4,2 e 31/37 A, D, E, G, K, N, Q, R, S 191 G -0.509 7 -1.031, -0.127 8,5 b 31/37 A, G, W 192 P 1.087 3 0.213, 1.502 5,3 e 31/37 A, E, I, K, L, P, S, T, V 193 V -0.226 6 -0.703, 0.090 7,5 b 31/37 E, I, S, T, V 194 L 0.900 4 0.090, 1.502 5,3 e 31/37 A, D, H, L, S, V 195 L 0.121 5 -0.481, 0.504 6,4 b 31/37 I, L, P, V, Y 196 P -0.938 8 -1.350, -0.703 9,7 b 31/37 M, P 197 D 2.819 1 1.502, 3.368 3,1 e 31/37 D, E, G, H, I, K, L, M, N, R, T 198 N 0.114 5 -0.481, 0.504 6,4 e 31/37 D, H, K, N, Y 199 H -1.178 9 -1.498, -1.031 9,8 b s 31/37 H, Q 200 Y -0.318 6 -0.771, -0.022 7,5 b 31/37 H, T, V, Y 201 L 0.562 4 -0.127, 1.156 5,3 b 31/37 H, I, L, M, N, V 202 S 0.885 4 0.213, 1.502 5,3 e 31/37 C, H, K, Q, S, T, Y 203 T 1.474 3 0.684, 2.026 4,2 e 31/37 A, C, F, K, N, S, T, V, Y 204 Q 0.374 4 -0.223, 0.895 6,4 e 31/37 G, H, K, M, Q, R, S, W 205 S 1.828 2 0.895, 2.026 4,2 e 31/37 F, I, L, N, S, T, V 206 A 2.456 1 1.156, 3.368 3,1 e 31/37 A, D, E, I, K, L, S, T, V 207 L 0.071 5 -0.557, 0.504 7,4 b 31/37 C, F, I, L, Y 208 S -0.953 8 -1.283, -0.771 9,7 e f 31/37 G, S, T 209 K -0.826 8 -1.156, -0.631 9,7 e f 31/37 K, R, T, V 210 D -1.145 9 -1.498, -0.968 9,8 e f 31/37 D, V 211 P 0.513 4 -0.127, 0.895 5,4 e 31/37 A, L, P, R, S, V 212 N 0.635 4 -0.022, 1.156 5,3 e 31/37 D, E, H, K, N, R, S, T 213 E -0.892 8 -1.219, -0.703 9,7 e f 31/37 D, E 214 K 2.113 2 0.895, 3.368 4,1 e 31/37 D, E, H, K, N, P, R, T 215 R -1.015 8 -1.350, -0.838 9,8 e f 33/37 K, R, T 216 D -1.221 9 -1.498, -1.094 9,8 e f 33/37 D, E 217 H -1.179 9 -1.498, -1.031 9,8 e f 31/37 H, N 218 M -0.499 7 -0.903, -0.223 8,6 b 31/37 I, L, M 219 V 1.615 3 0.684, 2.026 4,2 b 31/37 C, I, L, M, N, S, T, V 220 L 0.621 4 -0.022, 1.156 5,3 b 31/37 F, I, L, M, V, Y 221 L 1.162 3 0.351, 1.502 4,3 e 31/37 A, F, H, I, K, L, N, R, V 222 E -1.413 9 -1.691, -1.350 9,9 e f 31/37 E 223 F 1.728 3 0.684, 2.026 4,2 b 31/37 F, I, K, Q, S, T, V, Y 224 V 1.916 2 0.895, 3.368 4,1 b 30/37 F, I, L, N, R, T, V 225 T 1.882 2 0.895, 3.368 4,1 e 29/37 H, K, M, N, R, S, T, V 226 A -1.371 9 -1.691, -1.283 9,9 b s 28/37 A 227 A 0.288 5 -0.399, 0.684 6,4 b 25/37 A, C, I, S, V 228 G 0.185 5 -0.557, 0.684 7,4 b 20/37 A, D, G, N 229 I -0.628 7 -1.156, -0.314 9,6 b 15/37 H, I 230 T 0.081 5 -0.631, 0.504 7,4 e 15/37 D, K, T 231 H 1.512 3 0.351, 2.026 4,2 b 13/37 H, L, P 232 G 0.071 5 -0.771, 0.684 7,4 b 13/37 G, H 233 M -0.386 6 -1.031, -0.022 8,5 e 12/37 M, R 234 D -0.801 7 -1.350, -0.481 9,6 e 12/37 D 235 E -0.917 8 -1.420, -0.631 9,7 e f 13/37 E 236 L 0.541 4 -0.399, 1.156 6,3 e 13/37 A, L, R 237 Y -0.158 5* -0.903, 0.351 8,4 e 13/37 F, Y 238 K 0.197 5 -0.631, 0.684 7,4 e 12/37 K, R, S *Below the confidence cut-off - The calculations for this site were performed on less than 6 non-gaped homologue sequences, or the confidence interval for the estimated score is equal to- or larger than- 4 color grades.